These attacks cause inflammation often damaging the myelin in patches known as demyelination. Multiple sclerosis ms is a chronic inflammatory demyelinating disease of the central nervous system cns with an autoimmune role its pathogenesis. Ms is characterized by multifocal and temporally scattered central nervous system cns damage which lead to the axonal damage. Luciana parente costa seguro, sandra gofinet pasoto, in infection and autoimmunity second edition, 2015. Multiple sclerosis ms is a neurodegenerative disorder caused by the immune system mistakenly attacking the myelin sheath, or the protective protein coat around nerve fibers. Ms is thought to be an autoimmune disease that causes the bodys immune system to. Multiple sclerosis ms is the most common permanently disabling disorder of the central nervous system in young adults. The etiology of multiple sclerosis ms is complex, unpredictable, and unsystematic nerve.
Multiple sclerosis ms is a chronic inflammatory disease of the central nervous system cns and the most common cause of. Multiple sclerosis ms is a chronic inflammatory disease. Since the disease remains poorly understood, there is no effective treatment of the disease process itself. In section 2, the history and definition of ms is examined as a prelimin. Links to pubmed are also available for selected references. Consequently, ms impairs the ability to transmit neurological signals throughout ones nervous system. Although the etiology and pathogenesis of ms remains unclear, the present documents illustrate that the cause of ms is multifactorial and. The etiology of multiple sclerosis ms is complex, unpredictable, and unsystematic nerve demyelination, axonal deterioration, and neuroaxonal loss. His findings led him to correlate the signs and symptoms of ms with the disease re. Ms diagnosis is based on clinical and radiological criteria magnetic resonance. Multiple sclerosis overview etiology of ms ms news today.
Multiple sclerosis etiology, diagnosis, and new treatment. New insights into the pathophysiology, however, are. The main agents responsible for the ms development include exogenous, environmental, and genetic factors. Multiple sclerosis in multiple sclerosis, the protective coating on nerve fibers myelin is damaged and may eventually be destroyed.
Depending on where the nerve damage occurs, ms can affect vision, sensation, coordination, movement, and bladder and bowel control. Although ms is thought by some scientists to be an autoimmune disease, others. Etiology of multiple sclerosis an overview sciencedirect topics. Where appropriate, documents were requested to support. The role of an environmental exposure infectious or toxic is confirmed in this study by the demonstration in orkney of clustering of cases in time and space. Learn multiple sclerosis pathophysiology with free interactive flashcards. Furthermore, the pathophysiology of ms can generate asymmetrical effects where one side of. Multiple sclerosis etiology and diagnostic potential. Studies in the orkney and shetland islands have demonstrated the highest rates of multiple sclerosis ms recorded. Convert emails from ms outlook to pdf files youtube. Multiple sclerosis, cell therapy, etiology, demyelination.
Pdf multiple sclerosis ms is characterized by degradation of the essential myelin sheath around the nerves in the white matter of the central. Multiple sclerosis remains something of a mystery, even with the multitudes of medical advancements in the field. Epidemiology and etiology of multiple sclerosis request pdf. Differential diagnosis, clinical features, and prognosis of multiple sclerosis. Choose from 500 different sets of multiple sclerosis pathophysiology flashcards on quizlet. Variant spelling of etiology ms glossary all about multiple sclerosis. Multiple sclerosis rarer forms of dementia about multiple sclerosis ms is thought to be an autoimmune disease that causes the bodys immune system to attack the protective coating myelin around nerve fibres in the central nervous system. Multiple sclerosis is a chronic disease that affects the central nervous system, especially the brain, spinal cord, and optic nerves.
Multiple sclerosis ms is a chronic inflammatory demyelinating disease of the central nervous system cns. It is known that the mechanism of this disease is to attack the myelin surrounding nerve fibers and to disrupt communication between the brain and the body, but the actual cause of this disease is still unknown. The main part of this paper documents the distribution of mortality and morbidity. People with ms may experience a wide range of symptoms throughout the course of the disease. Multiple sclerosis ms is a chronic inflammatory and demyelinating disease of autoimmune originate. Pathogenesis, symptoms, diagnoses and cellbased therapy. Arrange the office so that file cabinets, computer terminals and so on are. The etiology of multiple sclerosis is, at present, not definitely known, but genetic and environmental factors play a role in its causation. Get a printable copy pdf file of the complete article 545k, or click on a page image below to browse page by page. Multiple sclerosis ms is a complex neurodegenerative disease affecting the central nervous system cns. The etiology of multiple sclerosis, an autoimmune disease of the central nervous system, is still unknown, but some risk factors have been implicated in its pathogenesis, including an association of genetic susceptibility and environmental agents. Both genetic and environmental causes for ms have been suggested. Medical files and dna samples from 583 french multiple sclerosis patients and both of their parents were used. Multiple sclerosis symptoms and causes mayo clinic.
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